Mutated <i>FANCA</i> Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma

Mutated <i>FANCA</i> Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma

Fanconi Anaemia (FA) is a rare recessive genetic disorder characterized by a defective DNA repair mechanism. Although aplastic anaemia is the principal clinical sign in FA, patients develop a head and neck squamous cell carcinoma (HNSCC) with a frequency 500–700 folds higher than the general populat...

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Bibliographic Details
Main Authors: Nadia Bertola, Paolo Degan, Enrico Cappelli, Silvia Ravera
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
anaerobic glycolysis
antioxidant defences
autophagy
double-strand DNA damage
Fanconi Anaemia
HNSCC
Online Access:https://www.mdpi.com/2073-4409/11/15/2353

Internet

https://www.mdpi.com/2073-4409/11/15/2353

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