The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer

The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer

Poly (ADP-ribose) polymerase 1 (PARP1) is highly expressed in small cell lung cancer (SCLC) and has emerged as an attractive target for treatment of SCLC. However, the clinical significance of PARP1 expression in SCLC remains elusive. In this study, we showed that high PARP1 expression was associate...

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Bibliographic Details
Main Authors: Xing Bian, Xiaolin Wang, Qiuyan Zhang, Liying Ma, Guozhen Cao, Ao Xu, Jinhua Han, Jun Huang, Wenchu Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
small cell lung cancer
MYC paralog
PARP1
BET
DNA damage response
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.565820/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.565820/full

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