Human Single-chain Variable Fragments Neutralize Pseudomonas aeruginosa Quorum Sensing Molecule, 3O-C12-HSL, and Prevent Cells From the HSL-mediated Apoptosis

Human Single-chain Variable Fragments Neutralize Pseudomonas aeruginosa Quorum Sensing Molecule, 3O-C12-HSL, and Prevent Cells From the HSL-mediated Apoptosis

The quorum sensing (QS) signaling molecule, N-(3-oxododecanoyl)-L-homoserine lactone (3O-C12-HSL), contributes to the pathogenesis of Pseudomonas aeruginosa by regulating expression of the bacterial virulence factors that cause intense inflammation and toxicity in the infected host. As such, the QS...

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Bibliographic Details
Main Authors: Sirijan Santajit, Watee Seesuay, Kodchakorn Mahasongkram, Nitat Sookrung, Pornpan Pumirat, Sumate Ampawong, Onrapak Reamtong, Manas Chongsa-Nguan, Wanpen Chaicumpa, Nitaya Indrawattana
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Microbiology
Subjects:
Pseudomonas aeruginosa
quorum sensing
N-3-oxo-dodecanoyl-L-homoserine lactone (3O-C12-HSL)
apoptosis
human scFv
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01172/full

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https://www.frontiersin.org/article/10.3389/fmicb.2020.01172/full

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