Measurements, Thermodynamic Modeling, and a Hydrogen Bonding Study on the Solubilities of Metoprolol Succinate in Organic Solvents

Measurements, Thermodynamic Modeling, and a Hydrogen Bonding Study on the Solubilities of Metoprolol Succinate in Organic Solvents

The solubilities of metoprolol succinate (a cardioselective β1 adrenergic receptor) in methanol, ethanol, n-propanol, isopropanol, n-butanol, ethyl acetate, and acetone were measured at temperatures ranging from (278.2 to 318.2) K using a solid–liquid equilibrium method. The solub...

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Bibliographic Details
Main Authors: Jian Shen, Xianrui Liang, Hao Lei
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
metoprolol succinate
solubility
dissolution enthalpy
hydrogen bonding
thermodynamic model
Online Access:http://www.mdpi.com/1420-3049/23/10/2469

Internet

http://www.mdpi.com/1420-3049/23/10/2469

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