Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparibResearch in context

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparibResearch in context

Summary: Background: Loss of heterozygosity (LOH) diminishes genetic diversity within cancer genomes. A tumour arising in an individual heterozygous for a functional and a loss-of-function (LoF) allele of a gene occasionally retain only the LoF allele. This can result in deficiency of specific prot...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Xiaonan Zhang, Natallia Rameika, Lei Zhong, Verónica Rendo, Margus Veanes, Snehangshu Kundu, Sandro Nuciforo, Jordan Dupuis, Muhammad Al Azhar, Ioanna Tsiara, Pauline Seeburger, Shahed Al Nassralla, Viktor Ljungström, Richard Svensson, Ivaylo Stoimenov, Per Artursson, Markus H. Heim, Daniel Globisch, Tobias Sjöblom
বিন্যাস: প্রবন্ধ
ভাষা:English
প্রকাশিত: Elsevier 2024-11-01
মালা:EBioMedicine
বিষয়গুলি:
Loss of heterozygosity
Loss of function
Hepatocellular carcinomas
CYP2D6 and talazoparib
অনলাইন ব্যবহার করুন:http://www.sciencedirect.com/science/article/pii/S2352396424004043

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http://www.sciencedirect.com/science/article/pii/S2352396424004043

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