Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice

Effects of lesion environments on transplanted neural progenitor cells (NPC) are not well characterized. Here, the authors show that NPC transplanted into CNS lesions generate cells that share transcriptional and functional features with host wound repair astroglia in mice.

Bibliographic Details
Main Authors: T. M. O’Shea, Y. Ao, S. Wang, A. L. Wollenberg, J. H. Kim, R. A. Ramos Espinoza, A. Czechanski, L. G. Reinholdt, T. J. Deming, M. V. Sofroniew
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33382-x