Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding
DCML deficiency is a disorder marked by loss of multiple immune cell types. Mutations that affect a single allele of the GATA2 transcription factor may lead to DCML by interfering with normal GATA2 binding, altering expression of important immune cell pathways.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03316-w |