Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level

Fine tuning the immune response in line with the degree of threat is central to recognition of a pathogen versus commensal bacteria. Here the authors implicate a digital all-or-nothing cell response in control of the tissue level immune response.

Bibliographic Details
Main Authors: Helen R. Clark, Connor McKenney, Nathan M. Livingston, Ariel Gershman, Seema Sajjan, Isaac S. Chan, Andrew J. Ewald, Winston Timp, Bin Wu, Abhyudai Singh, Sergi Regot
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22070-x