Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

Abstract Background Current human influenza vaccines lack the adaptability to match the mutational rate of the virus and therefore require annual revisions. Because of extensive manufacturing times and the possibility that antigenic alterations occur during viral vaccine strain production, an inhere...

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Bibliographic Details
Main Authors: Patrick Tjok Joe, Ioanna Christopoulou, Lien van Hoecke, Bert Schepens, Tine Ysenbaert, Carlo Heirman, Kris Thielemans, Xavier Saelens, Joeri L. Aerts
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Translational Medicine
Subjects:
mRNA
Influenza
Universal vaccine
Intranodal
Nucleoprotein
T cell
Online Access:http://link.springer.com/article/10.1186/s12967-019-1991-3

Internet

http://link.springer.com/article/10.1186/s12967-019-1991-3

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