Immune Response in Moderate to Critical Breakthrough COVID-19 Infection After mRNA Vaccination

Immune Response in Moderate to Critical Breakthrough COVID-19 Infection After mRNA Vaccination

SARS-CoV-2 variants of concern (VOCs) can trigger severe endemic waves and vaccine breakthrough infections (VBI). We analyzed the cellular and humoral immune response in 8 patients infected with the alpha variant, resulting in moderate to fatal COVID-19 disease manifestation, after double mRNA-based...

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Bibliographic Details
Main Authors: Krystallenia Paniskaki, Moritz Anft, Toni L. Meister, Corinna Marheinecke, Stephanie Pfaender, Sarah Skrzypczyk, Felix S. Seibert, Constantin J. Thieme, Margarethe J. Konik, Sebastian Dolff, Olympia Anastasiou, Bodo Holzer, Ulf Dittmer, Christine Queren, Lutz Fricke, Hana Rohn, Timm H. Westhoff, Oliver Witzke, Ulrik Stervbo, Toralf Roch, Nina Babel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
vaccine
mRNA
breakthrough infection
T cells
neutralizing antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.816220/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.816220/full

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