Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme

Evaluation of DNA adduct damage using G-quadruplex-based DNAzyme

Toxicity assessment is a major problem in pharmaceutical candidates and industry chemicals development. However, due to the lack of practical analytical methods for DNA adduct analysis, the safety evaluation of drug and industry chemicals was severely limited. Here, we develop a DNAzyme-based method...

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Bibliographic Details
Main Authors: Yi Xiao, Haomin Yi, Jingzhi Zhu, Suhua Chen, Guofang Wang, Yilong Liao, Yuanyuan Lei, Liyin Chen, Xingcai Zhang, Fangfu Ye
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-05-01
Series:Bioactive Materials
Subjects:
Toxicity assessment
DNAzyme
DNA adduct Damage
Styrene oxide
Pharmaceutical candidates
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22004261

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http://www.sciencedirect.com/science/article/pii/S2452199X22004261

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