The Association of <i>HLA-B*35</i> and <i>GSTT1</i> Genotypes and Hepatotoxicity in Thai People Living with HIV
Glutathione s-transferase (GST) is a family of drug-metabolizing enzymes responsible for metabolizing and detoxifying drugs and xenobiotic substances. Therefore, deletion polymorphisms of <i>GST</i>s can be implicated in developing several pathological conditions, including antiretrovira...
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MDPI AG
2022-06-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/6/940 |
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| author | Noppadol Chanhom Jiraphun Jittikoon Sukanya Wattanapokayakit Surakameth Mahasirimongkol Angkana Charoenyingwattana Wanvisa Udomsinprasert Usa Chaikledkaew Supharat Suvichapanich Taisei Mushiroda Sasisopin Kiertiburanakul Archawin Rojanawiwat Wittaya Wangsomboonsiri Weerawat Manosuthi Pacharee Kantipong Anucha Apisarnthanarak Wilawan Sangsirinakakul Pawinee Wongprasit Romanee Chaiwarith Woraphot Tantisiriwat Somnuek Sungkanuparph Wasun Chantratita |
| author_facet | Noppadol Chanhom Jiraphun Jittikoon Sukanya Wattanapokayakit Surakameth Mahasirimongkol Angkana Charoenyingwattana Wanvisa Udomsinprasert Usa Chaikledkaew Supharat Suvichapanich Taisei Mushiroda Sasisopin Kiertiburanakul Archawin Rojanawiwat Wittaya Wangsomboonsiri Weerawat Manosuthi Pacharee Kantipong Anucha Apisarnthanarak Wilawan Sangsirinakakul Pawinee Wongprasit Romanee Chaiwarith Woraphot Tantisiriwat Somnuek Sungkanuparph Wasun Chantratita |
| author_sort | Noppadol Chanhom |
| collection | DOAJ |
| description | Glutathione s-transferase (GST) is a family of drug-metabolizing enzymes responsible for metabolizing and detoxifying drugs and xenobiotic substances. Therefore, deletion polymorphisms of <i>GST</i>s can be implicated in developing several pathological conditions, including antiretroviral drug-induced liver injury (ARVDILI). Notably, <i>GST</i> polymorphisms have been shown to be associated with ARVDILI risk. However, data on <i>GST</i> polymorphisms in the Thai population are limited. Therefore, this study investigated possible associations between <i>GST</i> genetic polymorphisms and ARVDILI development. A total of 362 people living with HIV (PLHIV) and 85 healthy controls from multiple centers were enrolled. <i>GSTM1</i> and <i>GSTT1</i> genetic polymorphisms were determined using polymerase chain reactions. In addition, HLA genotypes were determined using a sequence-based HLA typing method. After comparing <i>GST</i> genotypic frequencies, there was no significant difference between PLHIV and healthy volunteers. However, while observing the PLHIV group, <i>GSTT1</i> wild type was significantly associated with a 2.04-fold increased risk of ARVDILI (95%CI: 1.01, 4.14; <i>p</i> = 0.045). Interestingly, a combination of <i>GSTT1</i> wild type and <i>HLA-B*35:05</i> was associated with a 2.28-fold higher risk of ARVDILI (95%CI: 1.15, 4.50; <i>p</i> = 0.02). Collectively, <i>GSTT1</i> wild type and a combination of <i>GSTT1</i> wild type plus <i>HLA-B*35:05</i> were associated with susceptibility to ARVDILI in the Thai population. |
| first_indexed | 2024-03-09T23:20:52Z |
| format | Article |
| id | doaj.art-c947fc5618e14a819ae4957935f74913 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:20:52Z |
| publishDate | 2022-06-01 |
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| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-c947fc5618e14a819ae4957935f749132023-11-23T17:28:00ZengMDPI AGJournal of Personalized Medicine2075-44262022-06-0112694010.3390/jpm12060940The Association of <i>HLA-B*35</i> and <i>GSTT1</i> Genotypes and Hepatotoxicity in Thai People Living with HIVNoppadol Chanhom0Jiraphun Jittikoon1Sukanya Wattanapokayakit2Surakameth Mahasirimongkol3Angkana Charoenyingwattana4Wanvisa Udomsinprasert5Usa Chaikledkaew6Supharat Suvichapanich7Taisei Mushiroda8Sasisopin Kiertiburanakul9Archawin Rojanawiwat10Wittaya Wangsomboonsiri11Weerawat Manosuthi12Pacharee Kantipong13Anucha Apisarnthanarak14Wilawan Sangsirinakakul15Pawinee Wongprasit16Romanee Chaiwarith17Woraphot Tantisiriwat18Somnuek Sungkanuparph19Wasun Chantratita20Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandDepartment of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandGenomic Medicine Centre, Division of Genomic Medicine and Innovation Support, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, ThailandGenomic Medicine Centre, Division of Genomic Medicine and Innovation Support, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, ThailandGenomic Medicine Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandSocial Administrative Pharmacy Division, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandDepartment of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandLaboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, JapanDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandClinical Research Center, Department of Medical Sciences, Ministry of Public Health, Nonthaburi 11000, ThailandDepartment of Internal Medicine, Sawanpracharak Hospital, Nakornsawan 60000, ThailandInternal Medicine, Bamrasnaradura Infectious Diseases Institute, Nonthaburi 11000, ThailandDepartment of Internal Medicine, Chiangrai Prachanukroh Hospital, Chiang Rai 57000, ThailandDivision of Infectious Diseases, Department of Medicine, Thammasat University Hospital, Pathum Thani 12121, ThailandInternal Medicine, Maharaj Nakorn Ratchasima Hospital, Nakorn Ratchasima 30000, ThailandInternal Medicine, Buriram Hospital, Buri Ram 31000, ThailandDepartment of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Preventive Medicine and Social Medicine, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, ThailandChakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan 10540, ThailandGenomic Medicine Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandGlutathione s-transferase (GST) is a family of drug-metabolizing enzymes responsible for metabolizing and detoxifying drugs and xenobiotic substances. Therefore, deletion polymorphisms of <i>GST</i>s can be implicated in developing several pathological conditions, including antiretroviral drug-induced liver injury (ARVDILI). Notably, <i>GST</i> polymorphisms have been shown to be associated with ARVDILI risk. However, data on <i>GST</i> polymorphisms in the Thai population are limited. Therefore, this study investigated possible associations between <i>GST</i> genetic polymorphisms and ARVDILI development. A total of 362 people living with HIV (PLHIV) and 85 healthy controls from multiple centers were enrolled. <i>GSTM1</i> and <i>GSTT1</i> genetic polymorphisms were determined using polymerase chain reactions. In addition, HLA genotypes were determined using a sequence-based HLA typing method. After comparing <i>GST</i> genotypic frequencies, there was no significant difference between PLHIV and healthy volunteers. However, while observing the PLHIV group, <i>GSTT1</i> wild type was significantly associated with a 2.04-fold increased risk of ARVDILI (95%CI: 1.01, 4.14; <i>p</i> = 0.045). Interestingly, a combination of <i>GSTT1</i> wild type and <i>HLA-B*35:05</i> was associated with a 2.28-fold higher risk of ARVDILI (95%CI: 1.15, 4.50; <i>p</i> = 0.02). Collectively, <i>GSTT1</i> wild type and a combination of <i>GSTT1</i> wild type plus <i>HLA-B*35:05</i> were associated with susceptibility to ARVDILI in the Thai population.https://www.mdpi.com/2075-4426/12/6/940drug-induced liver injuryglutathione s-transferasehuman immunodeficiency virushepatotoxicityadverse drug reactiongenetic polymorphisms |
| spellingShingle | Noppadol Chanhom Jiraphun Jittikoon Sukanya Wattanapokayakit Surakameth Mahasirimongkol Angkana Charoenyingwattana Wanvisa Udomsinprasert Usa Chaikledkaew Supharat Suvichapanich Taisei Mushiroda Sasisopin Kiertiburanakul Archawin Rojanawiwat Wittaya Wangsomboonsiri Weerawat Manosuthi Pacharee Kantipong Anucha Apisarnthanarak Wilawan Sangsirinakakul Pawinee Wongprasit Romanee Chaiwarith Woraphot Tantisiriwat Somnuek Sungkanuparph Wasun Chantratita The Association of <i>HLA-B*35</i> and <i>GSTT1</i> Genotypes and Hepatotoxicity in Thai People Living with HIV Journal of Personalized Medicine drug-induced liver injury glutathione s-transferase human immunodeficiency virus hepatotoxicity adverse drug reaction genetic polymorphisms |
| title | The Association of <i>HLA-B*35</i> and <i>GSTT1</i> Genotypes and Hepatotoxicity in Thai People Living with HIV |
| title_full | The Association of <i>HLA-B*35</i> and <i>GSTT1</i> Genotypes and Hepatotoxicity in Thai People Living with HIV |
| title_fullStr | The Association of <i>HLA-B*35</i> and <i>GSTT1</i> Genotypes and Hepatotoxicity in Thai People Living with HIV |
| title_full_unstemmed | The Association of <i>HLA-B*35</i> and <i>GSTT1</i> Genotypes and Hepatotoxicity in Thai People Living with HIV |
| title_short | The Association of <i>HLA-B*35</i> and <i>GSTT1</i> Genotypes and Hepatotoxicity in Thai People Living with HIV |
| title_sort | association of i hla b 35 i and i gstt1 i genotypes and hepatotoxicity in thai people living with hiv |
| topic | drug-induced liver injury glutathione s-transferase human immunodeficiency virus hepatotoxicity adverse drug reaction genetic polymorphisms |
| url | https://www.mdpi.com/2075-4426/12/6/940 |
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