Taxanorm: a novel taxa-specific normalization approach for microbiome data

Taxanorm: a novel taxa-specific normalization approach for microbiome data

Abstract Background In high-throughput sequencing studies, sequencing depth, which quantifies the total number of reads, varies across samples. Unequal sequencing depth can obscure true biological signals of interest and prevent direct comparisons between samples. To remove variability due to differ...

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Bibliographic Details
Main Authors: Ziyue Wang, Dillon Lloyd, Shanshan Zhao, Alison Motsinger-Reif
Format: Article
Language:English
Published: BMC 2024-09-01
Series:BMC Bioinformatics
Subjects:
Sequencing depth
Normalization
Microbiome
High-throughput sequencing
Online Access:https://doi.org/10.1186/s12859-024-05918-z

Internet

https://doi.org/10.1186/s12859-024-05918-z

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