Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis

Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis

Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis, which is a pathological process characterized by extracellular matrix accumulation. NR4A2 is a nuclear receptor belonging to the NR4A subfamily and vital in regulating cell growth, metabolism, inflammation and other biological func...

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Bibliographic Details
Main Authors: Pengguo Chen, Jie Li, Yan Huo, Jin Lu, Lili Wan, Bin Li, Run Gan, Cheng Guo
Format: Article
Language:English
Published: PeerJ Inc. 2015-12-01
Series:PeerJ
Subjects:
Fibrosis
Hepatic stellate cell
MAPK
NR4A2
Proliferation
Online Access:https://peerj.com/articles/1518.pdf

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