β-lactam-induced OMV release promotes polymyxin tolerance in Salmonella enterica sv. Typhi

β-lactam-induced OMV release promotes polymyxin tolerance in Salmonella enterica sv. Typhi

The rise of multidrug-resistant bacteria is a global concern, leading to a renewed reliance on older antibiotics like polymyxins as a last resort. Polymyxins, cationic cyclic peptides synthesized nonribosomally, feature a hydrophobic acyl tail and positively charged residues. Their antimicrobial mec...

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Bibliographic Details
Main Authors: Pedro Marchant, Erika Vivanco, Andrés Silva, Jan Nevermann, Ignacio Fuentes, Boris Barrera, Carolina Otero, Iván L. Calderón, Fernando Gil, Juan A. Fuentes
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Microbiology
Subjects:
outer membrane vesicles (OMV)
Salmonella enterica serovar Typhi
polymyxin
beta lactam antibiotic
cross-resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1389663/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1389663/full

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