β-lactam-induced OMV release promotes polymyxin tolerance in Salmonella enterica sv. Typhi
The rise of multidrug-resistant bacteria is a global concern, leading to a renewed reliance on older antibiotics like polymyxins as a last resort. Polymyxins, cationic cyclic peptides synthesized nonribosomally, feature a hydrophobic acyl tail and positively charged residues. Their antimicrobial mec...
Main Authors: | Pedro Marchant, Erika Vivanco, Andrés Silva, Jan Nevermann, Ignacio Fuentes, Boris Barrera, Carolina Otero, Iván L. Calderón, Fernando Gil, Juan A. Fuentes |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2024-03-01
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Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1389663/full |
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