Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer

Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer

<i>E4F1</i> is essential for early embryonic mouse development and for controlling the balance between proliferation and survival of actively dividing cells. We previously reported that E4F1 is essential for the survival of murine p53-deficient cancer cells by controlling the expression...

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Bibliographic Details
Main Authors: Kalil Batnini, Thibault Houles, Olivier Kirsh, Stanislas Du Manoir, Mehdi Zaroual, Hélène Delpech, Chloé Fallet, Matthieu Lacroix, Laurent Le Cam, Charles Theillet, Claude Sardet, Geneviève Rodier
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
E4F1 transcription factor
DNA Damage Response (DDR)
ATM/ATR-CHK checkpoint pathway
triple-negative breast cancer
chemotherapy
Online Access:https://www.mdpi.com/1422-0067/23/16/9217

Internet

https://www.mdpi.com/1422-0067/23/16/9217

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