Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress

Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress

Objective: ASCL1, a pioneer transcription factor, is essential for neural cell differentiation and function. Previous studies have shown that Ascl1 expression is increased in pancreatic β-cells lacking functional KATP channels or after feeding of a high fat diet (HFD) suggesting that it may contribu...

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Dettagli Bibliografici
Autori principali: Anna B. Osipovich, Frank Y. Zhou, Judy J. Chong, Linh T. Trinh, Mathew A. Cottam, Shristi Shrestha, Jean-Philippe Cartailler, Mark A. Magnuson
Natura: Articolo
Lingua:English
Pubblicazione: Elsevier 2023-12-01
Serie:Molecular Metabolism
Soggetti:
Ascl1
Pancreatic beta cell
Metabolic stress
Dedifferentiation
Insulin secretion
Islet innervation
Accesso online:http://www.sciencedirect.com/science/article/pii/S221287782300145X

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http://www.sciencedirect.com/science/article/pii/S221287782300145X

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