Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog

Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog

Adeno-associated viral (AAV) vectors have traditionally been viewed as predominantly nonintegrating, with limited concerns for oncogenesis. However, accumulating preclinical data have shown that AAV vectors integrate more often than previously appreciated, with the potential for genotoxicity. To und...

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Bibliographic Details
Main Authors: Lucas Van Gorder, Bhavya S. Doshi, Elinor Willis, Timothy C. Nichols, Emma Cook, John K. Everett, Elizabeth P. Merricks, Valder R. Arruda, Frederic D. Bushman, Mary Beth Callan, Benjamin J. Samelson-Jones
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
gene therapy
genotoxicity
integration
cancer
lymphoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123001985

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http://www.sciencedirect.com/science/article/pii/S2329050123001985

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