Novel insights in the pathomechanism of Brugada syndrome and fever‐related type 1 ECG changes in a preclinical study using human‐induced pluripotent stem cell‐derived cardiomyocytes

Novel insights in the pathomechanism of Brugada syndrome and fever‐related type 1 ECG changes in a preclinical study using human‐induced pluripotent stem cell‐derived cardiomyocytes

Abstract Background Brugada syndrome (BrS) is causing sudden cardiac death (SCD) mainly at young age. Studying the underlying mechanisms associated with BrS type I electrocardiogram (ECG) changes in the presence of fever and roles of autophagy for BrS remains lacking. Objectives We sought to study t...

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Bibliographic Details
Main Authors: Yingrui Li, Hendrik Dinkel, Dalia Pakalniskyte, Alexandra Viktoria Busley, Lukas Cyganek, Rujia Zhong, Feng Zhang, Qiang Xu, Lasse Maywald, Assem Aweimer, Mengying Huang, Zhenxing Liao, Zenghui Meng, Chen Yan, Timo Prädel, Lena Rose, Alexander Moscu‐Gregor, Alyssa Hohn, Zhen Yang, Lin Qiao, Andreas Mügge, Xiaobo Zhou, Ibrahim Akin, Ibrahim El‐Battrawy
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Clinical and Translational Medicine
Subjects:
autophaghy
Brugada syndrome
cardiac arrest
induced pluripotent stem cells
inflammation
sudden cardiac death
Online Access:https://doi.org/10.1002/ctm2.1130

Internet

https://doi.org/10.1002/ctm2.1130

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