Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

Abstract Age‐related macular degeneration (AMD) is a major cause of blindness in the elderly population. Its pathophysiology is linked to reactive oxygen species (ROS) and activation of the complement system. Sialic acid polymers prevent ROS production of human mononuclear phagocytes via the inhibit...

Full description

Bibliographic Details
Main Authors: Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz‐Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann
Format: Article
Language:English
Published: Springer Nature 2016-12-01
Series:EMBO Molecular Medicine
Subjects:
age‐related macular degeneration
complement
microglia
polysialic acid
SIGLEC
Online Access:https://doi.org/10.15252/emmm.201606627

Internet

https://doi.org/10.15252/emmm.201606627

Similar Items