Inferring cell-type-specific causal gene regulatory networks during human neurogenesis

Abstract Background Genetic variation influences both chromatin accessibility, assessed in chromatin accessibility quantitative trait loci (caQTL) studies, and gene expression, assessed in expression QTL (eQTL) studies. Genetic variants can impact either nearby genes (cis-eQTLs) or distal genes (tra...

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Bibliographic Details
Main Authors: Nil Aygün, Dan Liang, Wesley L. Crouse, Gregory R. Keele, Michael I. Love, Jason L. Stein
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-023-02959-0