Inferring cell-type-specific causal gene regulatory networks during human neurogenesis

Inferring cell-type-specific causal gene regulatory networks during human neurogenesis

Abstract Background Genetic variation influences both chromatin accessibility, assessed in chromatin accessibility quantitative trait loci (caQTL) studies, and gene expression, assessed in expression QTL (eQTL) studies. Genetic variants can impact either nearby genes (cis-eQTLs) or distal genes (tra...

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Bibliographic Details
Main Authors: Nil Aygün, Dan Liang, Wesley L. Crouse, Gregory R. Keele, Michael I. Love, Jason L. Stein
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Genome Biology
Subjects:
Causal inference
Gene regulatory networks
Quantitative trait loci
Cis- and trans-regulation
Neurogenesis
Online Access:https://doi.org/10.1186/s13059-023-02959-0

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