Implication of the PTN/RPTPβ/ζ Signaling Pathway in Acute Ethanol Neuroinflammation in Both Sexes: A Comparative Study with LPS

Implication of the PTN/RPTPβ/ζ Signaling Pathway in Acute Ethanol Neuroinflammation in Both Sexes: A Comparative Study with LPS

Binge drinking during adolescence increases the risk of alcohol use disorder, possibly by involving alterations of neuroimmune responses. Pleiotrophin (PTN) is a cytokine that inhibits Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. PTN and MY10, an RPTPβ/ζ pharmacological inhibitor, modulate etha...

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Bibliographic Details
Main Authors: María Rodríguez-Zapata, Milagros Galán-Llario, Héctor Cañeque-Rufo, Julio Sevillano, María Gracia Sánchez-Alonso, José M. Zapico, Marcel Ferrer-Alcón, María Uribarri, Beatriz de Pascual-Teresa, María del Pilar Ramos-Álvarez, Gonzalo Herradón, Carmen Pérez-García, Esther Gramage
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Biomedicines
Subjects:
pleiotrophin
Midkine
PTPRZ1
neuroinflammation
alcohol
adolescence
Online Access:https://www.mdpi.com/2227-9059/11/5/1318

Internet

https://www.mdpi.com/2227-9059/11/5/1318

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