Monocrotaline Toxicity Alters the Function of Hepatocyte Membrane Transporters in Rats

Monocrotaline Toxicity Alters the Function of Hepatocyte Membrane Transporters in Rats

Pyrrolizidine alkaloid monocrotaline (MCT) induces sinusoidal obstruction syndrome (SOS) in rats characterised by a sinusoidal congestive obstruction. Additionally, MCT administration decreases the biliary excretion of gadobenate dimeglumine (BOPTA), a hepatobiliary substrate used in clinical imagin...

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Bibliographic Details
Main Authors: Catherine M. Pastor, Valérie Vilgrain
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
sinusoidal obstruction syndrome
hepatocyte transporters
perfused rat livers
hepatocyte concentrations
clearances
Online Access:https://www.mdpi.com/1422-0067/23/14/7928

Internet

https://www.mdpi.com/1422-0067/23/14/7928

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