Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response

Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response

Abstract Background Cardiac fibrosis is the hallmark of all forms of chronic heart disease. Activation and proliferation of cardiac fibroblasts are the prime mediators of cardiac fibrosis. Existing studies show that ROS and inflammatory cytokines produced during fibrosis not only signal proliferativ...

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Bibliographic Details
Main Authors: Sandip Kumar Rath, Gunsmaa Nyamsuren, Björn Tampe, David Sung-wen Yu, Melanie S. Hulshoff, Denise Schlösser, Sabine Maamari, Michael Zeisberg, Elisabeth M. Zeisberg
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Clinical Epigenetics
Subjects:
TET3
Homologous recombination
Non-homologous end joining
TGF-ß
Fibrosis
Online Access:https://doi.org/10.1186/s13148-024-01719-6

Internet

https://doi.org/10.1186/s13148-024-01719-6

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