Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.

Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.

Although the vitamin A metabolite retinoic acid (RA) plays a critical role in immune function, RA synthesis during infection is poorly understood. Here, we show that retinal dehydrogenases (Raldh), required for the synthesis of RA, are induced during a retinoid-dependent type-2 immune response elici...

Full description

Bibliographic Details
Main Authors: Mara J Broadhurst, Jacqueline M Leung, K C Lim, Natasha M Girgis, Uma Mahesh Gundra, Padraic G Fallon, Mary Premenko-Lanier, James H McKerrow, Joseph M McCune, P'ng Loke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3426520?pdf=render

Internet

http://europepmc.org/articles/PMC3426520?pdf=render

Similar Items