Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD+ precursor nicotinamide riboside

Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD+ precursor nicotinamide riboside

Replication stress, caused by Rev1 deficiency, is associated with mitochondrial dysfunction, and metabolic stress. However, the overall metabolic alterations and possible interventions to rescue the deficits due to Rev1 loss remain unclear. Here, we report that loss of Rev1 leads to intense changes...

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Bibliographic Details
Main Authors: Sharath Anugula, Zhiquan Li, Yuan Li, Alexander Hendriksen, Peter Bjarn Christensen, Lin Wang, Jonathan M. Monk, Niels de Wind, Vilhelm A. Bohr, Claus Desler, Robert K. Naviaux, Lene Juel Rasmussen
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
Rev1
Replication stress
NAD+
Nicotinamide riboside
Healthspan
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023046005

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023046005

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