Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment

Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment

Background: Studying within-host genetic diversity of Mycobacterium tuberculosis (Mtb) in patients during treatment may identify adaptations to antibiotic and immune pressure. Understanding the significance of genetic heteroresistance, and more specifically heterozygous resistance-associated variant...

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Bibliographic Details
Main Authors: Camus Nimmo, Kayleen Brien, James Millard, Alison D. Grant, Nesri Padayatchi, Alexander S. Pym, Max O'Donnell, Richard Goldstein, Judith Breuer, François Balloux
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:EBioMedicine
Subjects:
Mycobacterium tuberculosis
TB
Heteroresistance
Genetic diversity
Bedaquiline
Whole genome sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420301225

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http://www.sciencedirect.com/science/article/pii/S2352396420301225

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