Morinda officinalis oligosaccharides mitigate chronic mild stress-induced inflammation and depression-like behaviour by deactivating the MyD88/PI3K pathway via E2F2

Morinda officinalis oligosaccharides mitigate chronic mild stress-induced inflammation and depression-like behaviour by deactivating the MyD88/PI3K pathway via E2F2

Morinda officinalis oligosaccharides (MOs) are natural herbal extracts that have been shown to exert antidepressant effects. However, the mechanism of this effect remains unclear. Here, we explored the mechanism by which MOs improved experimental depression. Using a chronic mild stress (CMS) murine...

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Bibliographic Details
Main Authors: Zhen-Hua Zhu, Xu-Yuan Yin, Tu-Sun Xu, Wei-Wei Tao, Guang-Da Yao, Pei-Jie Wang, Qi Qi, Qiu-Fang Jia, Jing Wang, Yue Zhu, Li Hui
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
depression
inflammation
MyD88/PI3K
E2F2
morinda officinalis oligosaccharides
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.855964/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.855964/full

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