Lung microbiome composition and bronchial epithelial gene expression in patients with COPD versus healthy individuals: a bacterial 16S rRNA gene sequencing and host transcriptomic analysis

Lung microbiome composition and bronchial epithelial gene expression in patients with COPD versus healthy individuals: a bacterial 16S rRNA gene sequencing and host transcriptomic analysis

Summary: Background: Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation and bacterial dysbiosis. The relationship between the airway microbiome and bronchial gene expression in COPD is poorly understood. We aimed to identify differences in the airway microbiome from...

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Main Authors: Mohammadali Yavari Ramsheh, PhD, Koirobi Haldar, PhD, Anna Esteve-Codina, PhD, Lillie F Purser, MSc, Matthew Richardson, PhD, Joachim Müller-Quernheim, ProfPhD, Timm Greulich, PhD, Adam Nowinski, PhD, Imre Barta, PhD, Mariarita Stendardo, PhD, Piera Boschetto, PhD, Damian Korzybski, PhD, Antje Prasse, ProfPhD, David G Parr, ProfPhD, Jens M Hohlfeld, PhD, Balázs Döme, PhD, Tobias Welte, ProfPhD, Simon Heath, PhD, Ivo Gut, ProfPhD, Julie A Morrissey, ProfPhD, Loems Ziegler-Heitbrock, ProfPhD, Michael R Barer, ProfPhD, Dave Singh, ProfPhD, Christopher E Brightling, ProfPhD
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:The Lancet Microbe
Online Access:http://www.sciencedirect.com/science/article/pii/S2666524721000355

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http://www.sciencedirect.com/science/article/pii/S2666524721000355

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