Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically audiogenic seizure model

Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically audiogenic seizure model

Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy research. Increasingly used to advance this field, the genetically audiogenic seizure hamster from Salamanca (GASH/Sal...

Full description

Bibliographic Details
Main Authors: Sandra M. Díaz-Rodríguez, M. Javier Herrero-Turrión, Carlos García-Peral, Ricardo Gómez-Nieto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
animal models of epilepsy
GASH/Sal
GluK1
glutamatergic system
kainate receptor
neurotransmission
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1322750/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1322750/full

Similar Items