Impact of an irreversible β-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos

Impact of an irreversible β-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos

Krabbe disease is a sphingolipidosis characterized by the genetic deficiency of the acid hydrolase β-galactosylceramidase (GALC). Most of the studies concerning the biological role of GALC performed on Krabbe patients and Galc-deficient twitcher mice (an authentic animal model of the disease) indica...

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Bibliographic Details
Main Authors: Jessica Guerra, Mirella Belleri, Giulia Paiardi, Chiara Tobia, Davide Capoferri, Marzia Corli, Elisa Scalvini, Marco Ghirimoldi, Marcello Manfredi, Rebecca C. Wade, Marco Presta, Luca Mignani
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Lipidomics
Galactosylceramidase
Krabbe disease
Molecular modeling
Zebrafish
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702400076X

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http://www.sciencedirect.com/science/article/pii/S200103702400076X

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