Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment.

Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment.

Microbes, including viruses, influence type 1 diabetes (T1D) development, but many such influences remain undefined. Previous work on underlying immune mechanisms has focussed on cytokines and T cells. Here, we compared two nonobese diabetic (NOD) mouse colonies, NODlow and NODhigh, differing marked...

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Bibliographic Details
Main Authors: Alessandra De Riva, Maja Wållberg, Francesca Ronchi, Richard Coulson, Andrew Sage, Lucy Thorne, Ian Goodfellow, Kathy D McCoy, Miyuki Azuma, Anne Cooke, Robert Busch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181964&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181964&type=printable

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