Design of 1-(furan-2-yl)-N-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl) methanimine derivatives as Enoyl-ACP reductase inhibitors: Synthesis, molecular docking studies and anti-tubercular activity

Design of 1-(furan-2-yl)-N-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl) methanimine derivatives as Enoyl-ACP reductase inhibitors: Synthesis, molecular docking studies and anti-tubercular activity

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A series of 5-phenylsubstiuted 1, 3, 4 thiadiazoles clubbed with furan moiety (Fa-Fe) by means of azomethine linkage have been synthesized. All the newly synthesized compounds were characterized by IR,1HNMR and Mass analyses. All the synthesized molecules have been predicted as anti-tubercular in na...

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Bibliographic Details
Main Authors: Bijo Mathew, Githa Elizabeth Mathew, George Sonia, Anila Kumar, Neethu P Charles, Palanisamy Kumar
Format: Article
Language:English
Published: Bangladesh Pharmacological Society 2013-08-01
Series:Bangladesh Journal of Pharmacology
Subjects:
KeEnol-ACP reductase
Molecular docking
1;3;4-thiadiazole
Online Access:http://www.banglajol.info/bd/index.php/BJP/article/view/14778

Internet

http://www.banglajol.info/bd/index.php/BJP/article/view/14778

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