Silencing of the Ca<sup>2+</sup> Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice

Silencing of the Ca<sup>2+</sup> Channel ORAI1 Improves the Multi-Systemic Phenotype of Tubular Aggregate Myopathy (TAM) and Stormorken Syndrome (STRMK) in Mice

Tubular aggregate myopathy (TAM) and Stormorken syndrome (STRMK) form a clinical continuum associating progressive muscle weakness with additional multi-systemic anomalies of the bones, skin, spleen, and platelets. TAM/STRMK arises from excessive extracellular Ca<sup>2+</sup> entry due t...

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Bibliographic Details
Main Authors: Roberto Silva-Rojas, Laura Pérez-Guàrdia, Emma Lafabrie, David Moulaert, Jocelyn Laporte, Johann Böhm
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
tubular aggregate myopathy
Stormorken syndrome
muscle disorder
calcium
STIM1
ORAI1
Online Access:https://www.mdpi.com/1422-0067/23/13/6968

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https://www.mdpi.com/1422-0067/23/13/6968

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