Increased UHMWPE Particle-Induced Osteolysis in Fetuin-A-Deficient Mice

Increased UHMWPE Particle-Induced Osteolysis in Fetuin-A-Deficient Mice

Particle-induced osteolysis is a major cause of aseptic prosthetic loosening. Implant wear particles stimulate tissue macrophages inducing an aseptic inflammatory reaction, which ultimately results in bone loss. Fetuin-A is a key regulator of calcified matrix metabolism and an acute phase protein. W...

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Bibliographic Details
Main Authors: Christina Polan, Christina Brenner, Monika Herten, Gero Hilken, Florian Grabellus, Heinz-Lothar Meyer, Manuel Burggraf, Marcel Dudda, Willi Jahnen-Dechent, Christian Wedemeyer, Max Daniel Kauther
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Journal of Functional Biomaterials
Subjects:
implants
arthroplasty
aseptic prosthetic loosening
osteolysis
particle-induced osteolysis
mouse calvaria osteolysis model
Online Access:https://www.mdpi.com/2079-4983/14/1/30

Internet

https://www.mdpi.com/2079-4983/14/1/30

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