Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: A PET study with [11C]acetate in humans

Oxidative metabolism of astrocytes is not reduced in hepatic encephalopathy: A PET study with [11C]acetate in humans

In patients with impaired liver function and hepatic encephalopathy (HE), consistent elevations of blood ammonia concentration suggest a crucial role in the pathogenesis of HE. Ammonia and acetate are metabolized in brain both primarily in astrocytes. Here, we used dynamic [11C]acetate PET of the b...

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Bibliographic Details
Main Authors: Peter eIversen, Kim eMouridsen, Mikkel Bo Hansen, Svend Borup Jensen, Michael eSørensen, Lasse Kristoffer eBak, Helle S Waagepetersen, Arne eSchousboe, Peter eOtt, Hendrik eVilstrup, Susanne eKeiding, Albert eGjedde
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Neuroscience
Subjects:
Astrocytes
Mitochondria
brain energy metabolism
kinetic modelling
Positron emission tomography.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00353/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00353/full

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