Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes

Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetes

Abstract Background Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic insulin-secreting $$\beta$$ β  cells. A comprehensive immune cell phenotype evaluation in T1DM has not been performed thus far at the single-ce...

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Bibliographic Details
Main Authors: Mohammad Amin Honardoost, Andreas Adinatha, Florian Schmidt, Bobby Ranjan, Maryam Ghaeidamini, Nirmala Arul Rayan, Michelle Gek Liang Lim, Ignasius Joanito, Quy Xiao Xuan Lin, Deepa Rajagopalan, Shi Qi Mok, You Yi Hwang, Anis Larbi, Chiea Chuen Khor, Roger Foo, Bernhard Otto Boehm, Shyam Prabhakar
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Genome Medicine
Subjects:
Type 1 diabetes mellitus (T1DM)
Peripheral blood mononuclear cells (PBMCs)
Single-cell RNA sequencing (scRNA-seq)
Online Access:https://doi.org/10.1186/s13073-024-01300-z

Internet

https://doi.org/10.1186/s13073-024-01300-z

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