Soluble T Cell Receptor Vβ Domains Engineered for High-Affinity Binding to Staphylococcal or Streptococcal Superantigens

Soluble T Cell Receptor Vβ Domains Engineered for High-Affinity Binding to Staphylococcal or Streptococcal Superantigens

Staphylococcus aureus and group A Streptococcus secrete a collection of toxins called superantigens (SAgs), so-called because they stimulate a large fraction of an individual’s T cells. One consequence of this hyperactivity is massive cytokine release leading to severe tissue inflammation and, in so...

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Bibliographic Details
Main Authors: Preeti Sharma, Ningyan Wang, David M. Kranz
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Toxins
Subjects:
superantigens
yeast display
directed evolution
affinity maturation
T-cell receptor
complementarity determining regions
framework regions
Online Access:http://www.mdpi.com/2072-6651/6/2/556

Internet

http://www.mdpi.com/2072-6651/6/2/556

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