A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro

A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro

Sensorineural hearing loss is irreversible and is associated with the loss of spiral ganglion neurons (SGNs) and sensory hair cells within the inner ear. Improving spiral ganglion neuron (SGN) survival, neurite outgrowth, and synaptogenesis could lead to significant gains for hearing-impaired patien...

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Bibliographic Details
Main Authors: Judith S. Kempfle, Marlon V. Duro, Andrea Zhang, Carolina D. Amador, Richard Kuang, Ryan Lu, Boris A. Kashemirov, Albert S. Edge, Charles E. McKenna, David H. Jung
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
inner ear
regeneration
synaptopathy
neurotrophin-3
bisphosphonate
small molecule
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.666706/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.666706/full

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