Structural basis of ribosomal RNA transcription regulation

Ribosomal RNA (rRNA) expression is regulated at the initiation stage of RNA synthesis. Here, the authors report cryo-EM structures of E. coli RNA polymerase and rRNA promoter complex with DksA/ppGpp on the way to open complex formation, identifying key steps in promoter recognition and opening.

Bibliografiset tiedot
Päätekijät: Yeonoh Shin, M. Zuhaib Qayyum, Danil Pupov, Daria Esyunina, Andrey Kulbachinskiy, Katsuhiko S. Murakami
Aineistotyyppi: Artikkeli
Kieli:English
Julkaistu: Nature Portfolio 2021-01-01
Sarja:Nature Communications
Linkit:https://doi.org/10.1038/s41467-020-20776-y