UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1

UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1

Abstract Background Ubiquitin-like protein 4A (UBL4A) plays a significant role in protein metabolism and the maintenance of cellular homeostasis. In cancer, UBL4A represses tumorigenesis and is involved in various signaling pathways. Pancreatic ductal adenocarcinoma (PDAC) is still a major cause of...

Full description

Bibliographic Details
Main Authors: Hongze Chen, Le Li, Jisheng Hu, Zhongjie Zhao, Liang Ji, Chundong Cheng, Guangquan Zhang, Tao zhang, Yilong Li, Hua Chen, Shangha Pan, Bei Sun
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ubiquitin-like protein 4A, UBL4A
Lysosome associated membrane protein-1, LAMP1
Autophagy
Lysosome dysfunction
Pancreatic ductal adenocarcinoma, PDAC
Proliferation and metastasis
Online Access:http://link.springer.com/article/10.1186/s13046-019-1278-9

Internet

http://link.springer.com/article/10.1186/s13046-019-1278-9

Similar Items