TMEM52B-derived peptides inhibit generation of soluble E-cadherin and EGFR activity to suppress colon cancer growth and early metastasis

TMEM52B-derived peptides inhibit generation of soluble E-cadherin and EGFR activity to suppress colon cancer growth and early metastasis

Abstract Background Transmembrane protein 52B (TMEM52B) is a novel gene expressed widely in various normal human tissues; however, the biological function of TMEM52B in cancer remains largely unknown. Previously, we demonstrated that TMEM52B is a novel modulator of E-cadherin and EGFR activity, and...

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Bibliographic Details
Main Authors: Yunhee Lee, Dongjoon Ko, Junghwa Yoon, Semi Kim
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
TMEM52B
Peptide
Therapeutics
E-Cadherin
EGFR
β-Catenin
Online Access:https://doi.org/10.1186/s12967-025-06075-4

Internet

https://doi.org/10.1186/s12967-025-06075-4

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