A Critical Role for Perivascular Cells in Amplifying Vascular Leakage Induced by Dengue Virus Nonstructural Protein 1

A Critical Role for Perivascular Cells in Amplifying Vascular Leakage Induced by Dengue Virus Nonstructural Protein 1

ABSTRACT Dengue is the most prevalent arthropod-borne viral disease affecting humans, with severe dengue typified by potentially fatal microvascular leakage and hypovolemic shock. Blood vessels of the microvasculature are composed of a tubular structure of endothelial cells ensheathed by perivascula...

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Bibliographic Details
Main Authors: Yin P. Cheung, Valeria Mastrullo, Davide Maselli, Teemapron Butsabong, Paolo Madeddu, Kevin Maringer, Paola Campagnolo
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mSphere
Subjects:
dengue
hemorrhage
perivascular cell
pericyte
NS1
dengue fever
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00258-20

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