Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants

Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants

Summary: RAS guanosine triphosphatases (GTPases) are mutated in nearly 20% of human tumors, making them an attractive therapeutic target. Following our discovery that nucleotide-free RAS (apo RAS) regulates cell signaling, we selectively target this state as an approach to inhibit RAS function. Here...

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Bibliographic Details
Main Authors: Imran Khan, Akiko Koide, Mariyam Zuberi, Gayatri Ketavarapu, Eric Denbaum, Kai Wen Teng, J. Matthew Rhett, Russell Spencer-Smith, G. Aaron Hobbs, Ernest Ramsay Camp, Shohei Koide, John P. O'Bryan
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Cell Reports
Subjects:
monobody
anti-RAS biologics
lung cancer
pancreatic cancer
colon cancer
tumorigenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472200033X

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http://www.sciencedirect.com/science/article/pii/S221112472200033X

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