The loss of B7-H4 expression in breast cancer cells escaping from T cell cytotoxicity contributes to epithelial-to-mesenchymal transition

The loss of B7-H4 expression in breast cancer cells escaping from T cell cytotoxicity contributes to epithelial-to-mesenchymal transition

Abstract Background B7 homology 4 (B7-H4), a potential target for cancer therapy, has been demonstrated to inhibit T cell cytotoxicity in the early stages of breast cancer. However, B7-H4 manipulating breast tumor immune microenvironment (TIME) in the tumor progression remains unknown. Methods We en...

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Bibliographic Details
Main Authors: Linlin Zhou, Jichun Wu, Mei Ruan, Yonglei Xiao, Hailin Lan, Qiongwen Wu, Chen-Wei Yu, Qiuyu Zhang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Breast Cancer Research
Subjects:
B7-H4
Breast cancer
EMT
Stemness
T cell cytotoxicity
Online Access:https://doi.org/10.1186/s13058-023-01721-5

Internet

https://doi.org/10.1186/s13058-023-01721-5

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