Murine Models Provide New Insights Into Pathogenesis of Chronic Graft-Versus-Host Disease in Humans

Murine Models Provide New Insights Into Pathogenesis of Chronic Graft-Versus-Host Disease in Humans

Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy for hematologic malignancies, but its success is complicated by graft-versus-host disease (GVHD). GVHD can be divided into acute and chronic types. Acute GVHD represents an acute alloimmune inflammatory response initiated...

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Bibliographic Details
Main Authors: Qingxiao Song, Xiaohui Kong, Paul J. Martin, Defu Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
hematopoietic cell transplantation
chronic graft-versus-host disease
mouse models
tissue resident memory T cell
B cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.700857/full

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