Strong <italic toggle="yes">In Vivo</italic> Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant

Strong <italic toggle="yes">In Vivo</italic> Inhibition of HIV-1 Replication by Nullbasic, a Tat Mutant

ABSTRACT Nullbasic is a mutant form of the HIV-1 transcriptional activator protein (Tat) that strongly inhibits HIV-1 transcription and replication in lymphocytes in vitro. To investigate Nullbasic inhibition in vivo, we employed an NSG mouse model where animals were engrafted with primary human CD4...

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Bibliographic Details
Main Authors: Hongping Jin, Yifan Sun, Dongsheng Li, Min-Hsuan Lin, Mary Lor, Lina Rustanti, David Harrich
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
Nullbasic
animal models
antiviral agents
gene transfer
human immunodeficiency virus
Online Access:https://journals.asm.org/doi/10.1128/mBio.01769-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01769-19

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