1,25-dihydroxyvitamin D3 ameliorates lupus nephritis through inhibiting the NF-κB and MAPK signalling pathways in MRL/lpr mice

1,25-dihydroxyvitamin D3 ameliorates lupus nephritis through inhibiting the NF-κB and MAPK signalling pathways in MRL/lpr mice

Abstract Background Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus (SLE). However, the aetiology and pathogenesis of LN remain unknown. 1,25-dihydroxyvitamin D3 [1,25-(OH)2-VitD3] is the active form of vitamin D, and it has been shown to perform important f...

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Bibliographic Details
Main Authors: Xuewei Li, Jie Liu, Yingzhe Zhao, Ning Xu, E. Lv, Chunzeng Ci, Xiangling Li
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Nephrology
Subjects:
MRL/lpr mice
1,25-dihydroxyvitamin D3
NF-κB and MAPK signalling pathways
Lupus nephritis
Online Access:https://doi.org/10.1186/s12882-022-02870-z

Internet

https://doi.org/10.1186/s12882-022-02870-z

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